Keratoderma palmoplantaris transgrediens [Mal de Meleda]: a case report

Mal de Meleda [keratoderma palmoplantaris transgrediens] is a rare autosomal recessive form of palmoplantar keratoderma with hyperkeratosis of palms and soles, which appears soon after birth and progressively involves other areas [transgrediens] of the skin especially dorsal aspects of hands and feet. We report a 20-year-old woman with Mal de Meleda with some unusual clinical features, i.e. peculiar finger nail anomalies and pseudoainhum on all her fingers

Skin lesions in 800 Iranian victims of mustard gas, 14-20 years after exposure

Mustard gas is a disabling chemical weapon and was widely used in First World War and Iraq-Iran war. Its toxic effects could be acute or chronic and they could particularly affect lungs, eyes and skin.To study the frequency of chronic complications of sulfur mustard gas in Iranian victims 14 to 20 years after exposure. This descriptive cross-sectional study was performed on 800 patients that were randomly selected from different provinces of Iran, who had been exposed to sulfur mustard gas during 1983 to 1988. These patients were clinically re-evaluated in 2002-2003 and laboratory tests were performed if necessary. The mean age of the patients at the time of study was 39.3 [ +/- 9.8] years. Three types of skin lesions were observed. Non-specific lesions including 39.6% xerosis, 19% pigmentary disorders, 17.4% cherry angioma, 12.7% seborrheic dermatitis, 12.2% eczema [dermatitis], 11.6% acneiform lesions, 7% tinea versicolor, 5.1% urticaria,, 3.6% vitiligo, 2.5% alopecia areata, 2% psoriasis, and 1.3% aphthous stomatitis. Specific skin lesion called mustard scar was defined according to morphology, location, history and observed in 44 [5.5%] patients. Malignant neoplasms including basal cell carcinoma, Bowen's disease, squamous cell carcinoma, mycosis fungoides and dermatofibrosarcoma protuberans occurred in 9 victims [1.1%]. Mustard gas can cause acute and late-onset skin lesions. Specific lesion of mustard gas called mustard scar is the most important finding of this study

[Association of sebaceous gland hyperplasia, wart, syringoma and irritation fibroma in a kidney transplant patient receiving long term cyclosporin and azathioprine]

Cyclosporin and azathioprine are immunosuppressive drugs, used widely in kidney transplant patients. A significant association between immunosuppressive therapy and multiple warts was described several years ago. There are also some reports of sebaceous gland hyperplasia in kidney transplant patients receiving cyclosporin. We report herein a 57-year-old woman who developed multiple warts on her hands and feet, lower lid syringomas, sebaceous gland hyperplasia of forehead and multiple mucosal irritation fibromas on tongue after kidney transplantation and a long course of treatment with oral cyclosporin, azathioprine and prednisolone since 6 years ago

[Scar due to sulfur mustard gas on thigh with cherry angiomas, decreased hair growth and pigmentary disorder: a case report]

Sulfur mustard or mustard gas has been widely used as a chemical weapon in the first world war and Iraq-Iran war. It causes acute and chronic complications in lungs, eyes and skin. In skin, mustard is toxic, mutagenic, and carcinogenic via alkylation of cellular proteins in enzymes, cell membranes, cytoplasm and particularly cell nucleus as well as in DNA components of the epidermis, dermis and skin appendages. Herein, we report a 37-year-old man who developed widespread blistering on his right thigh after sulfur mustard exposure in 1988. Now multiple cherry angiomas, decreased hair growth and pigmentary disorder are visible at the site of previous injury

[Localized darier's disease or acantholytic dyskeratotic epidermal nevus: a case report]

Patients with keratotic lesions distributed in a unilateral, linear, zosteriform or localized pattern and revealing histopathologic features of dyskeratoticacantholysis have been reported previously. There is some controversy in the appropriate nosologic classification of this entity. Some authors consider it as a localized form of Darier's disease while others place it as a variant of epidermal nevus. We report a 19-year-old girl who presented with 14 years history of an asymptomatic, hyperkeratotic area of skin-colored papules in a dermatomal distribution on the dorsum of her left hand and forearm. Pathological evaluation showed acantholysis and dyskeratosis. The controversy regarding the correct classification of such a patient is discussed